We focus on solving critical challenges in chemical transformations by improving performance through the discovery of innovative catalytic processes, the integration of multidisciplinary systems, and the manipulation of electrode-electrolyte microenvironments.
Developing Novel Biological Catalysts via Directed Evolution in Biohybrids
Nature has evolved a rich library of biological catalysts for essential processes which remain unmatched by synthetic catalysts. Biohybrids which integrates materials with biological systems allow to harness the exceptional efficiency and selectivity of biological catalysts. However, many chemical transformations critical to modern societal needs are absent in biological pathways.
We aim to develop a high-throughput, automatic biohybrid platform for directed evolution and screening of microbial catalysts capable of functioning under new reaction conditions, optimizing catalytic activity for new substrates, and catalyzing previously inaccessible chemical reactions.
Designing Advanced Material-Microbe Hybrids with Artificial Intelligence
The emerging field of material–microbe hybrids offers a promising solution for catalyzing cascade reactions by integrating synthetic materials with microbial components. However, current designs usually rely on trial-and-error approaches, particularly in selecting suitable microorganisms, which hinders progress in meeting catalytic demands. A more systematic and rational design strategy is urgently needed.
We aim to develop an AI-driven framework to guide the design of future material-microbe hybrids. By correlating the intrinsic biocatalytic properties of microorganisms with the performance of hybrid systems, the AI model will enable rational, data-driven system designs tailored to specific catalytic activities.
Manipulating the Microenvironment At and Near Solid-Electrolyte Interface
Electrochemical reactions predominantly occur at the solid-electrolyte interface where the microenvironment exhibits distinct properties compared to the bulk electrolyte, and this localized environment is crucial in determining the nature and efficiency of electrochemical processes.
We aim to investigate and manipulate the heterogeneity of the microenvironment near the solid-electrolyte interfaces for controlled chemical activity, addressing distinct needs in energy storage devices and electrocatalysis.